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Dialisi peritoneale

COMPARISON OF ANTIOXIDANT AND OXIDATIVE STRESS MARKERS IN DIALYSIS MODIALITIES FOR PACIENTS WITH CHRONIC KIDNEY DISEASE

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Abstract

Introduction. Reactive oxygen species (ROS) are involved in unleashing and aggravating various human pathologies. The association between non-enzymatic antioxidative capacity and serum levels of oxidative stress markers (advanced oxidation protein products, lipoperoxidation, reduction in thiol groups) is a good measure of an organism's oxidative status. It is known that in end stage renal disease (ESRD) oxidative stress increases, but there is no conclusive information. In this work, we intended to measure the antioxidative and oxidative stress capacity of plasma in CKD patients under dialysis treatment in two modalities, peritoneal dialysis (PD) and hemodialysis (HD), compared against apparently healthy controls.

Methods. We studied 822 subjects divided into three groups: 205 controls, 309 patients in PD and 308 in HD (56.08% were male (48.4 ± 17,9 years) and 43.92% females (47.9 ± 18.2 years)). All the patients cme from a multicentric study of hepatitis prevalence in patients with CKD in dialysis, where a plasma sample was taken for intended studies of oxidative stress. Advanced glucosylation products (AGEs) were measured as markers of glucosylation, and advanced oxidation protein products (AOPP) and carbonyls as markers of protein oxidation, and malondialdehyde (MDA) as marker of lipid peroxidation, with nitric oxide as a free radical. To measure antioxidative function, a determination was made of total thiols through measurement of SH groups, superoxide of dismutase (SOD) and vitamin C.

Results. We found that AGEs are increased in HD (14.06 ± 0.26) compared with PD (11.06 ± 0.26) (p <0.001). Patients on PD have higher concentration of vitamin C (1.28 ± 0.05) than HD patients (0.94 ± 0.05) (p <0.001). No significant differences were found with other markers. All oxidative markers were higher in patients than in controls; while the antioxidants were higher in controls than patients.

Conclusion. Patients with chronic kidney disease on PD suffer less oxidative damage than those on HD.

Acknowledgment: to Consejo Nacional de Ciencia y Tecnología (CONACyT) for financial support No. 115403, granted to JMG.

J. Gallardo(1), C. Rodríguez-López(1), M.J. Ventura(1), J.R. Paniagua(1)
((1)Instituto Mexicano del Seguro Social México, D.F. MEXICO)
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Realizzazione: Tesi S.p.A.

Per assistenza contattare: Claudia Ingrassia, Tesi S.p.A.
0172 476301 — claudia.ingrassia@gruppotesi.com