Login




Elementi traccia, metabolismo minerale e nefrolitiasi

PHASE I RESULTS OF THE MULTICENTRIC STUDY ON THE PREVALENCE OF VASCULAR CALCIFICATIONS AND VERTEBRAL FRACTURES IN PARATHYROIDECTOMISED (PTX) DIALYSIS PATIENTS (Cave PTX Study).

Questo Abstract è stato accettato come Poster.

Razionale

CAVE PTX study aims to evaluate, in dialysis patients submitted to PTX, the control and therapies of divalent ions (phase I), and the prevalence of aortic calcifications and vertebral fractures (phase II). We report here the phase I results.

Casistica e Metodi

Biochemistries and therapies of PTX patients were collected by means of an electronic data sheet from 149 Italian dialysis Units. A control group (C), comparable for age, sex and dialysis duration, was selected from the whole cohort.

Risultati

From a total of 12515 patients (HD = 87.7%;PD = 12.3%), 528(4.22%) had received PTX. Prevalence of PTX was definitely higher in HD(4.5%) compared to PD(1.9%). Cases and C(n=437) characteristics are compared in table 1.

 

Age,y

M/F,%

Dialysis,y

Ca,mg/dl

P,mg/dl

PTH,pg/ml

PTX

58±13

56/44

15±8

8.8±0.8

4.9±1.3

182±292

C

58±17

54/46

12±13(#)

9.0±0.7(#)

5.1±1.3(*)

334±294(#)

(*)p<.05, (#)p<.001 vs PTX.

Respectively in PTX and C, PTH was low(<150) in 64 vs 23%; optimal(150-300) in 17 vs 39%; and high(>300) in 19 vs 38%. Ca, P and PTH values in the three K/DOQI PTH range groups are in table 2.

PTH<150         PTH=150-300    PTH>300

 

PTX

C

PTX

C

PTX

C

Ca,mg/dl

8,6±0.8

9.0±0.9#

8.9±0.7

9.0±0.7

9.2±0.8

9.0±0.7#

P,mg/dl

4.8±1.3

4.9±1.5

4.9±1.3

4.8±1.2

5.1±1.3

5.5±1.3#

PTH,pg/ml

40±30

93±42#

216±40

223±41

630±417

577±331*

(*)p<.05; (#)p< 0.001, PTX vs C

Prescribed drugs, respectively in PTX and C, were: Vitamin D (61 vs 64%); Phosphate binders (88 vs 75%) and Calcimimetic (13 and 35%). Notably, Calcitriol and Ca based binders in PTX, and Paricalcitol and Sevelamer in C, were the most frequently prescribed drugs. 


Conclusioni

PTX has a low prevalence in Italy, and mainly involves relatively young, females and long-term haemodialysis patients. In these patients PTH values are mostly low and therapeutic choices are accordingly different. Different hard outcomes can be hypothesized.

Mazzaferro S. on behalf of the Italian Study Group on Mineral Metabolism and of the Contributing Italian Dialyis Centers
(Dept. of Cardiovascular Respiratory Nephrologic and Geriatric Sciences Sapienza University, Roma)
Non sono presenti commenti
Figure
Realizzazione: Tesi S.p.A.

Per assistenza contattare: Lucia Piumetto, Tesi S.p.A.
0172 476301 — lucia.piumetto@gruppotesi.com